THESIS:Phytochemical Analysis And Anti -Plasmodial Properties of Methanol Extract Of Guiera Senegalensis J.F. Gmel On Wister Albino Mice via oral route.

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Phytochemical Analysis And Anti -Plasmodial Properties of Methanol Extract Of Guiera Senegalensis J.F. Gmel On Wister Albino Mice via oral route.

Thesis Presented by


Mamza Afakirya Ushadari
Department Of Chemistry
Faculty of physical Science
University Of Benin
Benin-City
Edo State
Nigeria


ABSTRACT
Until recently the African region depended largely on plants for drugs to use for managing the common tropical diseases whose effects can lead to pandemics; With the advent of Western influence there has been a little drift in use and belief in single/few compound drugs but it is estimated that the majority of the Africans still depend on herbal concoctions, for various reasons. Guiera senegalensis J.F. Gmel (combretaceae) is acclaimed as a common herbal antipyretic and antimalarial among some tribal groups in northern Nigeria. The purpose of this of this study is to investigate the pytochemical analysis, antimalarial activity and the acute toxicity from Guiera senegalensis. Leaf extracts of the plant were thus tested for antimalarial activity and acute toxicity on white Wister albino mice weighing between 30-35g. Phytochemical screening revealed the presence of carbohydrate, , phenols, flavonoids, abundant tannins, alkaloid and saponins. Also it was observed that Guera senegalensis extracts has no toxic effect across the administered doses 100, 500 and 1000 mg/kg in the study. From the prophylactic study 100 and 200 mg/kg is more effective specifically at 200 mg/kg than the control groups in the reduction of the level of Plasmodium berghei. The extract exhibited anti-malarial properties for the curative study and standard drug drastically reduce the level of Plasmodium berghei as recorded from the percentage inhibition in the graded doses of treated plant (52 %, 46%, 80% and 47%).
Key words: Guiera senegalensis, antimalarial, prophylactic, curative phytochemical, acute toxicity.

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